September 12, 2020
HUTER Project Coordinator and Principal Investigator Prof. Carlos Simón MD, PhD. and Felip Vilella PhD. contribute in the HCA Latin American Virtual Workshop due on the 24th-25th September 2020.
“Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception”
“We investigated potential SARS-CoV-2 tropism in human endometrium by single-cell RNA-sequencing of viral entry-associated genes in healthy women. Percentages of endometrial cells expressing ACE2, TMPRSS2, CTSB, or CTSL were <2%, 12%, 80%, and 80%, respectively, with 0.7% of cells expressing all four genes. Our findings imply low efficiency of SARS-CoV-2 infection in the endometrium before embryo implantation, providing information to assess preconception risk in asymptomatic carriers.”
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The human uterus is a flagship reproductive organ with profound implications not only in reproduction but also in women’s health. HUTER can advance the Human Cell Atlas initiative for the exploitation potential in Obstetrics and Gynecology and biomedicine research areas such as Regenerative Medicine or Reproductive Medicine.
The uterus is itself a model for regenerative medicine since (i) endometrial tissue regenerates monthly and its transformation is executed through dynamic changes in states and interactions of multiple cell types, and (ii) myometrial tissue has remarkable regenerative capacity and extensive remodelling throughout pregnancy. Hence, the primary motivation HUTER proposal stems from the need to better understand the human uterus in order to more effectively address uterine diseases that impact women ́s health such as myomas or endometriosis and/or might contribute to infertility, infant and maternal mortality and morbidity.
HUTER technological and biological platform will be a crucial resource for the scientific and clinical communities to define the cellular basis of health and disease, allowing the rapid development of new diagnosis and prognosis tools and therapeutic advancements in the field.
The Human Cell Atlas (HCA) Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and provide a framework for understanding cellular dysregulation in human disease. About the Latin American Workshop This meeting seeks both to raise awareness about HCA in the Latin American scientific community and to nucleate groups who can contribute to HCA at a regional and global level. These groups could be working in single-cell or spatial analysis, as well as other areas. The first day of the workshop will highlight talks from the HCA scientific community, followed by a single cell technology showcase on the second day.
Please click here to see the schedule.